Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.12.011
Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.12.040
Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103149
Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.11.047
Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.11.023
Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.01.070
Design, synthesis and bioactivity evaluation of coumarin-chalcone hybrids as potential anticancer agents.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103530
Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.02.043
Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.02.037
A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.12.027
Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103565
Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
来源期刊:Bioorganic ChemistryDOI:10.1016/j.bioorg.2018.11.037
Bioactive scalemic caged xanthones from the leaves of Garcinia bracteata.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.10.041
Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.02.014
Design, synthesis and anticervical cancer activity of new benzofuran-pyrazol-hydrazono- thiazolidin-4-one hybrids as potential EGFR inhibitors and apoptosis inducing agents.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103035
2-Aryl-quinazolin-4(3H)-ones as an inhibitor of leishmania folate pathway: In vitro biological evaluation, mechanism studies and molecular docking.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.10.028
NO inhibitory phytochemicals as potential anti-inflammatory agents from the twigs of Trigonostemon heterophyllus.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.03.029
Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.03.014
Switching of Trp-214 intrinsic rotamer population in human serum albumin: An insight into the aftermath of embracing therapeutic bioorganic luminophore azapodophyllotoxin into sudlow site I.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.11.015
Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103434
Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.03.061
Side-chain cleaved phytoecdysteroid metabolites as activators of protein kinase B.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.10.049
Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κB-mediated transcription in HepG2 hepatoma cells.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103326
Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103076
Discovery of guaiane-type sesquiterpenoids from the roots of Daphne genkwa with neuroprotective effects.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103545
Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103472
Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) inhibitors.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.102991
Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.102996
Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2018.12.020
Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103473
Natural flavonoid α-glucosidase inhibitors from Retama raetam: Enzyme inhibition and molecular docking reveal important interactions with the enzyme active site.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.03.079
Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.102948
Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.02.022
Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103421
Development of carbapenem-based fluorogenic probes for the clinical screening of carbapenemase-producing bacteria.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103405
Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.01.013
Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103261
Design, synthesis and anti-HBV activity of NVR3-778 derivatives.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103363
The anti-cancer compound Schweinfurthin A targets Osh2 and disrupts lipid metabolism in the yeast model.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103471
Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs.
来源期刊:Bioorganic chemistryDOI:10.1016/J.BIOORG.2019.103163
Synthesis and in vitro antitumor activity of novel acylspermidine derivative N-(4-aminobutyl)-N-(3-aminopropyl)-8-hydroxy-dodecanamide (AAHD) against HepG2 cells.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.102937
Hydrolysis of surfactin over activated carbon.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.03.070
Neurological and psychiatric management using COMT inhibitors: A review.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103418
Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103305
Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103232
A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103141
Two novel classes of fused azaisocytosine-containing congeners as promising drug candidates: Design, synthesis as well as in vitro, ex vivo and in silico studies.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103480
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
来源期刊:Bioorganic chemistryDOI:10.1016/J.BIOORG.2019.103135
Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103445
Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluation.
来源期刊:Bioorganic chemistryDOI:10.1016/j.bioorg.2019.103241