Molecular Metabolism

Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

Impact of dietary sucrose on adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: liquid or solid

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice

A dual Ucp1 reporter mouse model for imaging and quantitation of brown and brite fat recruitment

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones

A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

Moderate weight loss attenuates chronic endoplasmic reticulum stress and mitochondrial dysfunction in human obesity

Transcriptional and physiological roles for STAT proteins in leptin action

Conditional deletion of melanin-concentrating hormone receptor 1 from GABAergic neurons increases locomotor activity

Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights

Double bond configuration of palmitoleate is critical for atheroprotection

Epigenetic regulation of diabetogenic adipose morphology

WWOX somatic ablation in skeletal muscles alters glucose metabolism

GLP-1 modulates the supramammillary nucleus-lateral hypothalamic neurocircuit to control ingestive and motivated behavior in a sex divergent manner

Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis

Diet-induced hypothalamic dysfunction and metabolic disease, and the therapeutic potential of polyphenols

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice

Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

Evaporative cooling provides a major metabolic energy sink

Ferritin regulates organismal energy balance and thermogenesis

HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo

A role for foregut tyrosine metabolism in glucose tolerance

Cognitive dysfunction in diabetic rats is prevented by pyridoxamine treatment. A multidisciplinary investigation

Interaction of circulating GLP-1 and the response of the dorsolateral prefrontal cortex to food-cues predicts body weight development

Discovering metabolic disease gene interactions by correlated effects on cellular morphology

Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity

Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen

Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice

A single extra copy of Down syndrome critical region 1–4 results in impaired hepatic glucose homeostasis

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation

Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism

GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury

α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles

Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity

Informing β-cell regeneration strategies using studies of heterogeneity

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation