mAbs

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

Nanobodies reveal an extra-synaptic population of SNAP-25 and Syntaxin 1A in hippocampal neurons

In vitro and in silico assessment of the developability of a designed monoclonal antibody library

Antigen binding allosterically promotes Fc receptor recognition

Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

Rapid single B cell antibody discovery using nanopens and structured light

Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease

Systematic development of temperature shift strategies for Chinese hamster ovary cells based on short duration cultures and kinetic modeling

Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis

Modulating cell culture oxidative stress reduces protein glycation and acidic charge variant formation

Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan

Redirected optimized cell killing (ROCK®): A highly versatile multispecific fit-for-purpose antibody platform for engaging innate immunity

The first World Health Organization International Standard for infliximab products: A step towards maintaining harmonized biological activity

Evolution of a comprehensive, orthogonal approach to sequence variant analysis for biotherapeutics

Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies

Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions

Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency

Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis

From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk

Influence of the bispecific antibody IgG subclass on T cell redirection

Optimization of a calcium-dependent Protein A-derived domain for mild antibody purification

Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

Using bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies

Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

Structural characterization of monoclonal antibodies targeting C-terminal Ser404region of phosphorylated tau protein.

Engineering an anti-CD52 antibody for enhanced deamidation stability

Selection and characterization of FcϵRI phospho-ITAM specific antibodies

The impact of standard accelerated stability conditions on antibody higher order structure as assessed by mass spectrometry

A general platform for antibody purification utilizing engineered-micelles

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.

Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics

Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities

Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico

Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics

Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6th antibody industrial symposium, June 25-26, 2018, Montpellier, France

Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

L445P mutation on heavy chain stabilizes IgG4 under acidic conditions

Identification and characterization of an IgG sequence variant with an 11 kDa heavy chain C-terminal extension using a combination of mass spectrometry and high-throughput sequencing analysis

NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies