Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00049
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00188
Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b01058
L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking
来源期刊:ACS Chemical BiologyDOI:10.1021/acschembio.9b00427
Esterase-Triggered Self-Immolative Thiocarbamates Provide Insights into COS Cytotoxicity.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00981
Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b01087
Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00369
Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00948
Processivity in Bacterial Glycosyltransferases
来源期刊:ACS Chemical BiologyDOI:10.1021/acschembio.9b00619
Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00088
Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b01025
Optimization of Ligands using Focused DNA-encoded Libraries to Develop a Selective, Cell-permeable CBX8 Chromodomain Inhibitor.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00654
Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00338
Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI
来源期刊:ACS Chemical BiologyDOI:10.1021/acschembio.8b00969
Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
来源期刊:ACS chemical biologyDOI:10.1021/ACSCHEMBIO.9B00172
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00354
Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00406
Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00490
Metabolic Regulation of the Epitranscriptome.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00951
Leveraging new definitions of the LxVP SLiM to discover novel Calcineurin regulators and substrates.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00606
Direct evidence for an enzyme generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00514
YTHDF2 recognition of N1-methyladenosine (m1A)-modified RNA is associated with transcript destabilization.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00655
Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00593
A Chemical Inhibitor of Cell Growth Reduces Cell Size in Bacillus subtilis.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b01066
Pandonodin: a proteobacterial lasso peptide with an exceptionally long C-terminal tail.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00676
Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00064
Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00989
Systematic diversity-oriented synthesis of reduced flavones from γ-pyrones to probe biological performance diversity.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00294
Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases.
来源期刊:ACS chemical biologyDOI:10.1021/ACSCHEMBIO.9B00323
Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa using DNA-Encoded Small Molecule Library Screening.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00905
Transcriptional Bypass of DNA-protein and DNA-peptide Conjugates by T7 RNA Polymerase.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00365
Lost in (Clinical) Translation: Recent Advances in Heparin Neutralization and Monitoring.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00772
An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00971
A single-component flavoenzyme catalyzed regioselective halogenation of pyrone in the biosynthesis of venemycins.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00554
Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00651
The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis
来源期刊:ACS Chemical BiologyDOI:10.1021/acschembio.9b00862
Identification of Bioactive Small Molecule Inhibitors of Separase.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00661
Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00292
Engineered chymotrypsiN for mass-spectrometry based detection of protein glycosylation.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00506
Activation of Ralfuranone/Ralstonin Production by Plant Sugars Functions in the Virulence of Ralstonia solanacearum.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00301
Amino Acid Residues Recognizing Isomeric Glutamate Substrates in UDP- N-acetylmuramic acid-l-alanine-glutamate Synthetases.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00159
High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b00802
Immunological Evaluation of Synthetic Glycosylphosphatidylinositol Glycoconjugates as Vaccine Candidates Against Malaria.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00739
Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.8b01021
A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00002
Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00529
Morphological Deconvolution of Beta-Lactam Polyspecificity in E. coli.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00141
Dimensionally Enhanced Antibacterial Library Screening.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00745
Immunity guided identification of threonyl-tRNA synthetase as the molecular target of obafluorin, a beta-lactone antibiotic.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00590
Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation.
来源期刊:ACS chemical biologyDOI:10.1021/acschembio.9b00610