European Journal of Pharmacology

Old wine in new bottles: Drug repurposing in oncology.

Parecoxib, a selective blocker of cyclooxygenase‐2, directly inhibits neuronal delayed‐rectifier K+ current, M‐type K+ current and Na+ current

Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-β1 signaling pathway.

Anticancer effect of pan‐PI3K inhibitor on multiple myeloma cells: Shedding new light on the mechanisms involved in BKM120 resistance

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure.

Puerarin inhibits vascular calcification of uremic rats.

(-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells.

Glabridin resensitizes p‐glycoprotein‐overexpressing multidrug‐resistant cancer cells to conventional chemotherapeutic agents

Vitamin D protects against diabetic nephropathy: Evidence-based effectiveness and mechanism.

In silico approaches for screening molecular targets in Candida albicans: A proteomic insight into drug discovery and development.

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.

Hematological malignancies and molecular targeting therapy.

Hydralazine protects against renal ischemia‐reperfusion injury in rats

Mast cell-mediated mechanistic pathways in organ transplantation.

EPA:DHA 6:1 is a superior omega‐3 PUFAs formulation attenuating platelets‐induced contractile responses in porcine coronary and human internal mammary artery by targeting the serotonin pathway via an increased endothelial formation of nitric oxide

Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis

Coiled‐coil domain‐containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression

Noradrenaline reuptake inhibition increases control of impulsive action by activating D1‐like receptors in the infralimbic cortex

Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.

Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase‐2 induction in HCA‐7 human colon cancer cells

Dysregulation of autophagy-related lncRNAs in peripheral blood of coronary artery disease patients.

iTRAQ‐based pharmacoproteomics reveals potential targets of berberine, a promising therapy for ulcerative colitis

Stearoyl lysophosphatidylcholine inhibits LPS‐induced extracellular release of HMGB1 through the G2A/calcium/CaMKK&bgr;/AMPK pathway

Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.

Pharmacology of Parsabiv® (etelcalcetide, ONO‐5163/AMG 416), a novel allosteric modulator of the calcium‐sensing receptor, for secondary hyperparathyroidism in hemodialysis patients

Bupivacaine‐induced contraction is attenuated by endothelial nitric oxide release modulated by activation of both stimulatory and inhibitory phosphorylation (Ser1177 and Thr495) of endothelial nitric oxide synthase

Suppressive effects of type I angiotensin receptor antagonists, candesartan and irbesartan on allergic asthma

The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats.

Therapeutic effect and mechanism study of L-cysteine derivative 5P39 on LPS-induced acute lung injury in mice.

Naringenin attenuates carotid restenosis in rats after balloon injury through its anti-inflammation and anti-oxidative effects via the RIP1-RIP3-MLKL signaling pathway.

Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.

TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice.

Simvastatin inhibits the proliferation of HL-60 clone 15- derived eosinophils by inducing the arrest of the cell cycle in the G1/S phase.

Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer.

Delta‐opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice

Formoterol counteracts the inhibitory effect of cigarette smoke on glucocorticoid‐induced leucine zipper (GILZ) transactivation in human bronchial smooth muscle cells

p38 mitogen activated protein kinase mediates cardiac Na+/H+ exchanger inhibition induced by Sildenafil

Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells.

DITMD‐induced mitotic defects and apoptosis in tumor cells by blocking the polo‐box domain‐dependent functions of polo‐like kinase 1

What is the impact of eukaryotic elongation factor 2 kinase on cancer: A systematic review.

Antidiabetic effects and sustained metabolic benefits of sub-chronic co-administration of exendin-4/gastrin and xenin-8-Gln in high fat fed mice.

Visfatin promotes the malignancy of human acute myeloid leukemia cells via regulation of IL‐17

Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3β/β-catenin pathway.

Cardioprotection of hydralazine against myocardial ischemia/reperfusion injury in rats.

Exogenous obestatin decreases beta‐cell apoptosis and alfa‐cell proliferation in high fat diet and streptozotocin induced type 2 diabetic rats

Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells.

Nitric oxide: Is it the culprit for the continued expansion of keloids?