Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.08.005
Luxturna: FDA documents reveal the value of a costly gene therapy.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.01.019
Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.11.003
Towards the development of human immune-system-on-a-chip platforms
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.10.003
Drug repurposing: a promising tool to accelerate the drug discovery process.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.06.014
Therapy for glioblastoma: is it working?
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.03.008
Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent evaluation.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.08.009
The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.11.022
PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.09.001
TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.12.001
Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.023
Recent advances in intraocular sustained-release drug delivery devices.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.031
Hydrogels for sustained delivery of biologics to the back of the eye.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.037
Evolution of commercially available compounds for HTS.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.10.016
Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.12.007
Alternative splicing, RNA-seq and drug discovery.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.03.030
Gut reaction: impact of systemic diseases on gastrointestinal physiology and drug absorption.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.11.009
Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.06.002
Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.01.015
3D in vitro models of tumors expressing EGFR family receptors: a potent tool for studying receptor biology and targeted drug development.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.09.003
Efficient drug discovery by rational lead hybridization based on crystallographic overlay.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.11.021
Harnessing nucleic acid-based therapeutics for atherosclerotic cardiovascular disease: state of the art.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.04.007
Exploring new technologies in biomedical research.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.04.001
The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.09.011
Antidepressants and nose-to-brain delivery: drivers, restraints, opportunities and challenges.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.06.001
Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.016
Advances in differentiation therapy for osteosarcoma.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.08.010
Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.11.002
The gap between the need for novel retinal drug delivery methods, technologies in R&D phase, and approved ocular drug delivery technologies.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.03.018
Unbiased data analytic strategies to improve biomarker discovery in precision medicine.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.018
Emerging targets of inflammation and tear secretion in dry eye disease.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.02.006
Mini-gut: a promising model for drug development.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.06.006
Recent developments in liposomal drug delivery systems for the treatment of retinal diseases.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.04.004
Targeting P2X7 receptors as a means for treating retinal disease.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.03.029
Multiscale modelling of drug mechanism and safety.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.12.009
Accelerated drug discovery by rapid candidate drug identification.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.03.026
Streamlining nonclinical drug development using the FDA 505(b)(2) new drug application regulatory pathway.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.07.005
The Horizon Scanning System at The Italian Medicines Agency.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.04.010
Site-specific bioconjugation and self-assembly technologies for multi-functional biologics: on the road to the clinic.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.10.002
Physiologically based ocular pharmacokinetic modeling using computational methods.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.039
Collaborative drug discovery and the Tres Cantos Antimalarial Set (TCAMS).
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.04.005
Impact of dosing schedule in animal experiments on compound progression decisions.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2018.11.006
Heterogeneous surface-modified nanoplatforms for the targeted therapy of haematological malignancies.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.10.001
Novel insights into the role of urotensin II in cardiovascular disease.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.08.005
Regulatory aspects and quality controls of polymer-based parenteral long-acting drug products: the challenge of approving copies.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.12.008
CDx, NGS and regulation: five perspectives from the Pistoia Alliance.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.07.002
Adverse drug reactions on sexual functioning: a systematic overview.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.01.012
Correlates of time to approval and other clinical development periods.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.027
Neuropharmacokinetics: a bridging tool between CNS drug development and therapeutic outcome.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.02.007
Drug discovery: a research sector stricken in France that can sometimes pay off.
来源期刊:Drug discovery todayDOI:10.1016/j.drudis.2019.05.002