Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00101-2
Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases
来源期刊:GeroScienceDOI:10.1007/s11357-019-00107-w
Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
来源期刊:GeroScienceDOI:10.1007/s11357-019-00113-y
The potential role of necroptosis in inflammaging and aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00131-w
Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00065-3
An expanding GSK3 network: implications for aging research
来源期刊:GeroScienceDOI:10.1007/s11357-019-00085-z
Sulfoaphane - role in aging and neurodegeneration
来源期刊:GeroScienceDOI:10.1007/s11357-019-00061-7
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
来源期刊:GeroScienceDOI:10.1007/s11357-019-00077-z
Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00111-0
Effect of caloric restriction and rapamycin on ovarian aging in mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00087-x
Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline
来源期刊:GeroScienceDOI:10.1007/s11357-019-00100-3
Gastro-intestinal and oral microbiome signatures associated with healthy aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00098-8
Taming expectations of metformin as a treatment to extend healthspan
来源期刊:GeroScienceDOI:10.1007/s11357-019-00057-3
The influence of GDF11 on brain fate and function
来源期刊:GeroScienceDOI:10.1007/s11357-019-00054-6
Assessment of age-related decline of neurovascular coupling responses by functional near-infrared spectroscopy (fNIRS) in humans
来源期刊:GeroScienceDOI:10.1007/s11357-019-00122-x
The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults
来源期刊:GeroScienceDOI:10.1007/s11357-019-00056-4
Genomic instability and innate immune responses to self-DNA in progeria
来源期刊:GeroScienceDOI:10.1007/s11357-019-00082-2
Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00102-1
Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr−/−:hApoB+/+ mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00070-6
Accelerated decline in cognition in a mouse model of increased oxidative stress
来源期刊:GeroScienceDOI:10.1007/s11357-019-00105-y
Astrocyte senescence contributes to cognitive decline
来源期刊:GeroScienceDOI:10.1007/s11357-019-00140-9
Genetic heterogeneity of Alzheimer’s disease in subjects with and without hypertension
来源期刊:GeroScienceDOI:10.1007/s11357-019-00071-5
Cellular energetics and mitochondrial uncoupling in canine aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00062-6
circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
来源期刊:GeroScienceDOI:10.1007/s11357-019-00120-z
Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles
来源期刊:GeroScienceDOI:10.1007/s11357-019-00109-8
The effects of cardiorespiratory fitness on executive function and prefrontal oxygenation in older adults
来源期刊:GeroScienceDOI:10.1007/s11357-019-00128-5
WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans
来源期刊:GeroScienceDOI:10.1007/s11357-019-00124-9
The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension
来源期刊:GeroScienceDOI:10.1007/s11357-019-00139-2
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease
来源期刊:GeroScienceDOI:10.1007/s11357-019-00127-6
Raman fingerprints as promising markers of cellular senescence and aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00053-7
Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies
来源期刊:GeroScienceDOI:10.1007/s11357-019-00090-2
Tryptophan metabolism is differently regulated between large and small dogs
来源期刊:GeroScienceDOI:10.1007/s11357-019-00114-x
Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain
来源期刊:GeroScienceDOI:10.1007/s11357-019-00067-1
Differential effects of various genetic mouse models of the mechanistic target of rapamycin complex I inhibition on heart failure
来源期刊:GeroScienceDOI:10.1007/s11357-019-00119-6
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions
来源期刊:GeroScienceDOI:10.1007/s11357-019-00108-9
The association of anxio-depressive disorders and depression with motoric cognitive risk syndrome: results from the baseline assessment of the Canadian longitudinal study on aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00093-z
Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations
来源期刊:GeroScienceDOI:10.1007/s11357-019-00112-z
Novel individualized power training protocol preserves physical function in adult and older mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00069-z
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells
来源期刊:GeroScienceDOI:10.1007/s11357-019-00099-7
Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases
来源期刊:GeroScienceDOI:10.1007/s11357-019-00106-x
Individual evaluation of luteinizing hormone in aged C57BL/6 J female mice
来源期刊:GeroScienceDOI:10.1007/s11357-019-00104-z
Lumbar spinal cord microglia exhibited increased activation in aging dogs compared with young adult dogs
来源期刊:GeroScienceDOI:10.1007/s11357-019-00133-8
Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging
来源期刊:GeroScienceDOI:10.1007/s11357-019-00141-8
Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation
来源期刊:GeroScienceDOI:10.1007/s11357-019-00094-y
Aging induced by D-galactose aggravates cardiac dysfunction via exacerbating mitochondrial dysfunction in obese insulin-resistant rats
来源期刊:GeroScienceDOI:10.1007/s11357-019-00132-9
Genetic conversion of proliferative astroglia into neurons after cerebral ischemia: a new therapeutic tool for the aged brain?
来源期刊:GeroScienceDOI:10.1007/s11357-019-00084-0
High rates of undiagnosed vascular cognitive impairment among American Indian veterans
来源期刊:GeroScienceDOI:10.1007/s11357-019-00055-5
The transfer of specific mitochondrial lipids and proteins to lipid droplets contributes to proteostasis upon stress and aging in the eukaryotic model system Saccharomyces cerevisiae
来源期刊:GeroScienceDOI:10.1007/s11357-019-00103-0
Correction to: Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells
来源期刊:GeroScienceDOI:10.1007/s11357-019-00144-5
Polygenic risk score for disability and insights into disability-related molecular mechanisms
来源期刊:GeroScienceDOI:10.1007/s11357-019-00125-8