ALTEX-Alternatives to Animal Experimentation

A three-dimensional model to study human synovial pathology.

Activation of TRPA1 by volatile organic chemicals leading to sensory irritation.

Beyond the 3Rs: Expanding the use of human-relevant replacement methods in biomedical research.

Toward Good In Vitro Reporting Standards.

Chemical hazard prediction and hypothesis testing using quantitative adverse outcome pathways.

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data.

Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard.

Botulinum toxin testing on animals is still a Europe-wide issue.

Characterizing sources of variability in zebrafish embryo screening protocols.

Developing context appropriate toxicity testing approaches using new alternative methods (NAMs).

The impact of precision uncertainty on predictive accuracy metrics of non-animal testing methods.

Investigating cell type specific mechanisms contributing to acute oral toxicity.

An in vitro coculture system for the detection of sensitization following aerosol exposure.

Rheumatoid arthritis research in the 21st century: Limitations of traditional models, new technologies, and opportunities for a human biology-based approach.

The HaCaT/THP-1 Cocultured Activation Test (COCAT) for skin sensitization: a study of intra-lab reproducibility and predictivity.

Software tools for literature screening in systematic reviews in biomedical research.

Chemical concentrations in cell culture compartments (C5) - concentration definitions.

Assessment of iron oxide nanoparticle ecotoxicity on regeneration and homeostasis in the replacement model system Schmidtea mediterranea.

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing.

Machine learning prediction of cyanobacterial toxin (microcystin) toxicodynamics in humans.

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays.

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

Insights into in vitro biokinetics using Virtual Cell Based Assay simulations.

Recent advances in 3Rs and laboratory animal science: Report on the International Conference of LASA (India).

Improved defined approaches for predicting skin sensitization hazard and potency in humans.

The current status of alternative methods for cosmetics safety assessment in China.

Comparison of in chemico skin sensitization methods and development of an in chemico skin photosensitization assay.

Innovative in vitro method to study ventilator induced lung injury.

Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques.

Presence of vasculature results in faster insulin response in adipocytes in vascularized adipose tissue model.

Extending the concept of predicting fish acute toxicity in vitro to the intestinal cell line RTgutGC.

Advice on avoiding the Valley of Death: insights from a 3Rs model of aversive and emetic compound identification.

Integrating adverse outcome pathways (AOPs) and high throughput in vitro assays for better risk evaluations, a study with drug-induced liver injury (DILI).

Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD Test Guidelines.

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging.

Zebrafish embryo and acute fish toxicity test show similar sensitivity for narcotic compounds.

Corrigendum to Normalization of data for viability and relative cell function curves.

Applications for animal experiments are rarely rejected in Germany.

Bisphenol A binding promiscuity: A virtual journey through the universe of proteins.

Corrigendum to A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays.

Corrigendum to Chemical concentrations in cell culture compartments (C⁵) - concentration definitions.

Use of alternative methods: From fundamental to industrial research.

Science and alternative methods: Integrated approaches.

Development of an ex vivo aneurysm model for vascular devices testing.

Corrigendum to Essential components of methods papers.

The value of organs-on-chip for regulatory safety assessment.