LABORATORY INVESTIGATION

Protective effect and mechanism of IL-10 on renal ischemia–reperfusion injury

Deep learning assisted mitotic counting for breast cancer

RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease

miR-483-5p decreases the radiosensitivity of nasopharyngeal carcinoma cells by targeting DAPK1

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury

Role of macrophage TRPV4 in inflammation

A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination

Autophagy-related 7 modulates tumor progression in triple-negative breast cancer

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis

Therapeutic potential of PLK1 inhibition in triple-negative breast cancer

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury through a reduction in oxidative stress and inflammation

Inhibition of prolyl hydroxylase domain (PHD) by JTZ-951 reduces obesity-related diseases in the liver, white adipose tissue, and kidney in mice with a high-fat diet

Inhibition of microRNA-21-5p reduces keloid fibroblast autophagy and migration by targeting PTEN after electron beam irradiation

Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency

Automated computerized image analysis for the user-independent evaluation of disease severity in preclinical models of NAFLD/NASH

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

Blockade of intercellular adhesion molecule-1 prevents angiotensin II-induced hypertension and vascular dysfunction

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease

Activation of death-associated protein kinase 1 promotes neutrophil apoptosis to accelerate inflammatory resolution in acute respiratory distress syndrome

SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer

Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway

Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage

Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory effect of 13-cis-retinoic acid on neuroblastoma through a TLR3-related immunogenic-apoptotic response

Co-staining of microRNAs and their target proteins by miRNA in situ hybridization and immunohistofluorescence on prostate cancer tissue microarrays

Fatty acid beta oxidation enzyme HADHA is a novel potential therapeutic target in malignant lymphoma

Mesenchyme-specific deletion of Tgf-β1 in the embryonic lung disrupts branching morphogenesis and induces lung hypoplasia

Mitochondrial dysfunction/NLRP3 inflammasome axis contributes to angiotensin II-induced skeletal muscle wasting via PPAR-γ

JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model

S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma

PD-L1 over-expression is driven by B-cell receptor signaling in diffuse large B-cell lymphoma

Unlocking bone for proteomic analysis and FISH

Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma

Reversal of TET-mediated 5-hmC loss in hypoxic fibroblasts by ascorbic acid

Genetic alterations in cell cycle regulation-associated genes may promote primary progression of gastrointestinal stromal tumors

Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation

Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon

ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

TRPV2 channel as a possible drug target for the treatment of heart failure

Prostaglandin E2 receptor EP1 (PGE2/EP1) deletion promotes glomerular podocyte and endothelial cell injury in hypertensive TTRhRen mice

Adipophilin expression in cutaneous malignant melanoma is associated with high proliferation and poor clinical prognosis

Castration-induced stromal remodeling disrupts the reconstituted prostate epithelial structure

TRPM7 mediates kidney injury, endothelial hyperpermeability and mortality during endotoxemia

High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer

Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling

In vivo monitoring of bone microstructure by propagation-based phase-contrast computed tomography using monochromatic synchrotron light

Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues