CLINICAL SCIENCE

New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.

Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.

Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD).

GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation.

Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.

Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis.

Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis.

HEG1 indicates poor prognosis and promotes hepatocellular carcinoma invasion, metastasis, and EMT by activating Wnt/β-catenin signaling.

SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice.

Trained immunity and diabetic vascular disease.

The vermiform appendix: an immunological organ sustaining a microbiome inoculum.

Involvement of serum amyloid A1 in the rupture of fetal membranes through induction of collagen I degradation.

Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells.

DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase.

Effect of Mycophenolate and Rapamycin on Renal Fibrosis in Lupus Nephritis.

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation.

SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma.

Targeting Bromodomain-containing proteins to prevent spontaneous preterm birth.

ZEB1-AS1 is associated with poor prognosis in non-small-cell lung cancer and influences cell migration and apoptosis by repressing ID1.

Adipocytes initiates an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high fat feeding.

Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy.

Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension.

Hyperglycemia-induced transcriptional regulation of ROCK1 and TGM2 expression is involved in small artery remodeling in obese diabetic Göttingen Minipigs.

Particulate matter exposure aggravates osteoarthritis severity.

Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.

First identification of PODXL nonsense mutations in autosomal dominant focal segmental glomerulosclerosis.

Depletion of CD11c+ dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth.

MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.

Processes exacerbating apoptosis in non-alcoholic steatohepatitis.

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7).

Role of Orexin-B/Orexin 2 receptor in myocardial protection.

Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases.

Impact of obesity-induced type 2 diabetes on long-term outcomes following stroke.

Relationship between renin-angiotensin-aldosterone system and renal Kir5.1 channels.

A novel function for HEG1 in promoting metastasis in hepatocellular carcinoma.

Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.

The human duodenal mucosa harbors all components for a local renin angiotensin system.

Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organisation.

Cyclosporine A promotes the therapeutic effect of mesenchymal stem cells on transplantation reaction.

Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?

Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease.

Specialized pro-resolving mediators in diabetes: novel therapeutic strategies.

Lack of adipose-specific hexose-6-phosphate dehydrogenase causes inactivation of adipose glucocorticoids and improves metabolic phenotype in mice.

Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe fetal growth restriction.

Electrolyte transport in the renal collecting duct and its regulation by the renin-angiotensin-aldosterone system.

Lipid metabolism participates in human membranous nephropathy identified by whole-genome gene expression profiling.