BIOORGANIC & MEDICINAL CHEMISTRY

The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells.

Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.

New hybrid trifluoromethylquinolines as antiplasmodium agents.

Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA.

Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies.

Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus.

Design, synthesis and antimycobacterial activity of less lipophilic Q203 derivatives containing alkaline fused ring moieties.

Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.

Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.

Veratric acid derivatives containing benzylidene-hydrazine moieties as promising tyrosinase inhibitors and free radical scavengers.

Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis.

Enantioselective resolution of side-chain modified gem-difluorinated alcohols catalysed by Candida antarctica lipase B and monitored by capillary electrophoresis.

Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.

Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.

Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.

2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships.

Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.

Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.

Design, synthesis and anti-inflammatory evaluation of novel pyrrolo[2,3-d]pyrimidin derivatives as potent JAK inhibitors.

Identification of potent pyrazole based APELIN receptor (APJ) agonists.

Developing new hybrid scaffold for urease inhibition based on carbazole-chalcone conjugates: Synthesis, assessment of therapeutic potential and computational docking analysis.

Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors.

Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.

Fluorogenic approach to evaluating prodrug hydrolysis and stability in live cells.

Synthesis and bioactivity of 1,3-thiazolidine-2-thione derivatives against type III secretion system of Xanthomonas oryzae.

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).

Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes.

Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity.

Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae.

Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.

Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.

Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents.

Development of novel macrocyclic small molecules that target CTG trinucleotide repeats.

Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.

Modelling the binding mode of macrocycles: Docking and conformational sampling.

Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents.

Chemical synthesis and functional characterization of a new class of ceramide analogues as anti-cancer agents.

Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid.

Design and synthesis of sulfonamidophenylethylamides as novel cardiac myosin activator.

Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions.

Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate \u200c on HCT-116 cell line.

Fluorine-18 (18F)-labeled retinoid\u202fx\u202freceptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands.

Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.

Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors.