NATURE STRUCTURAL & MOLECULAR BIOLOGY

An ultra high-throughput method for single-cell joint analysis of open chromatin and transcriptome

Atg2 mediates direct lipid transfer between membranes for autophagosome formation.

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome

Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Structural snapshots of actively transcribing influenza polymerase

Structural basis of tubulin detyrosination by the vasohibin–SVBP enzyme complex

The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition

Apn2 Resolves Blocked 3’ Ends and Suppresses Top1-Induced Mutagenesis at Genomic rNMP Sites.

Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts

An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections

A symmetric toggle switch explains the onset of random X inactivation in different mammals

Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions

Torque transmission mechanism of the curved bacterial flagellar hook revealed by cryo-EM

X-chromosome upregulation is driven by increased burst frequency

Transcription preinitiation complex structure and dynamics provide insight into genetic diseases

Cryo-EM structure of the ClpXP protein degradation machinery

Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.

Nascent-protein ubiquitination is required for heat shock–induced gene downregulation in human cells

A systems view of spliceosomal assembly and branchpoints with iCLIP

The peptide hormone glucagon forms amyloid fibrils with two coexisting beta-strand conformations.

Structural basis of tubulin detyrosination by vasohibins

Structures of human ENT1 in complex with adenosine reuptake inhibitors

Structural snapshots of actively transcribing influenza polymerase.

Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release

The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations

Enzymatic anti-CRISPRs improve the bacteriophage arsenal

Molecular mechanism of cotranslational membrane protein recognition and targeting by SecA

Tracking RNA structures as RNAs transit through the cell

FACT mediates cohesin function on chromatin

Aaron Klug (1926–2018)

Neutral epigenetic inheritance: being prepared for future generations

Structure of the P element transpososome reveals new twists on the DD(E/D) theme

Twist to disentangle

Dynein tails: how to hitch a ride on an IFT train

Capturing genome folds in single sensory neurons

Author Correction: The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

An RNA exporter that enforces a no-export policy

Hooked on motility

Publisher Correction: Five decades of eukaryotic transcription

Michael Rossmann, data-sharing champion

Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

Joseph F. Sambrook (1939–2019)

Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes

Reoviridae transcription is more than an open-and-shut case

Outlining the proton-conduction pathway in otopetrin channels