Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1119
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1218
Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-0065
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1453
A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-0839
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1151
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.cd-18-0830
The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-0959
Combination Olaparib and Temozolomide in Relapsed Small Cell Lung Cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0582
Altered RNA Processing in Cancer Pathogenesis and Therapy.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0399
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-0348
Tumor genomic profiling guides metastatic gastric cancer patients to targeted treatment: The VIKTORY Umbrella Trial.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0442
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1308
Distinct CRC-associated APC mutations dictate response to Tankyrase inhibition.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0289
Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-18-1138
Innate αβ T cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0161
Atezolizumab Combo Approved for PD-L1-positive TNBC.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-038
Genomics and Targeted Therapies in Gastroesophageal Adenocarcinoma.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-19-0487
Capivasertib Active against AKT1-Mutated Cancers.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2018-153
A Bispecific Antibody for MUC16 and CD3 Has Preclinical Antitumor Activity.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-099
GITR Agonism Overcomes Resistance to Immunotherapy in Solid Tumors.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-070
Brain Tumors Feed Off Healthy Neurons.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-117
Gilteritinib Likely New Standard Care for AML.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-046
Translesion Synthesis by DNA Polymerase θ Protects from Skin Cancers.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-025
R-Loops May Drive Embryonal Tumors with Multilayered Rosettes.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-186
Tumor Burden Affects Efficacy of Combination Immunotherapy.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-021
Enzalutamide Bests Older NSAAs in mHSPC.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-066
Fatty Acid Transport Regulates Neutrophil Function in Tumors.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-064
RAF Binding Preferences Dictate RAS-Mediated Tumorigenesis.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-158
NK Cells in the Tumor Microenvironment Have Fragmented Mitochondria.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-165
Oncogenic Gene Fusion-Derived Neoantigens Elicit Specific T-cell Responses.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-065
Structure-Based Design Identifies PROTAC Degraders of BAF Complex Subunits.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-094
Scientists See Human Cancer in Zebrafish.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-062
Bringing Oncohistones into the Fold.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.cd-19-0839
γ-Secretase Inhibitors Improve Multiple Myeloma BCMA CAR-T Therapy.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-153
3-D Imaging Reveals Why Tumors Grow In or Out.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-017
The PRIMPOL Protein Shields Replication Forks in BRCA-Deficient Cells.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-168
Mechanism of Cediranib/Olaparib Combo Revealed.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-064
NCI Paylines Drop as Grant Applications Climb.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-041
Rare Neuroepithelial Stem Cells May Underlie Small-Cell Lung Cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-154
Merck LAPs Up Tilos for Its TGFβ-Targeting Tech.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-077
AML Is Dependent on an RNA-Binding Protein Network.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-027
Pegilodecakin plus Anti-PD-1 Is Tolerable and Effective.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-152
Exact Sciences Buys Genomic Health for $2.8 Billion.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-099
New ADC Shrinks HER2-Positive Tumors.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-089
Lung Microbiota Promote Lung Cancer.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-019
Colon Cancer Data Key as Pfizer Buys Array.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-NB2019-075
The cGAS-STING Pathway Influences Taxane Response.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-111
YTHDF2 Is Required for Leukemia Stem Cells Function in AML.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-069
Tumor MHC-II Neoantigens Maintain CD8+ T-cell Antitumor Immunity.
来源期刊:Cancer discoveryDOI:10.1158/2159-8290.CD-RW2019-166