The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau5907
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aao5253
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau5758
Reproducing human and cross-species drug toxicities using a Liver-Chip
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax5516
Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw5680
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav2685
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau3776
Challenges for mesenchymal stromal cell therapies
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aat2189
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav7816
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau5266
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau2086
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav0537
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aar6659
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aas9292
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau3174
Shaping of infant B cell receptor repertoires by environmental factors and infectious disease
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aat2004
Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aat9321
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw7736
Clinical implications of tumor-intrinsic mechanisms regulating PD-L1
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav4810
Estimating cholera incidence with cross-sectional serology
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau6242
TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aan2585
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau6039
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau8866
DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay2736
A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aar3558
Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau0683
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau9732
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw2603
Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax9487
Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aau7411
Cognitive refractory state caused by spontaneous epileptic high-frequency oscillations in the human brain
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax7830
Twists and turns to translating 4-1BB cancer immunotherapy
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax4738
Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw2050
A once-a-month oral contraceptive
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay2602
Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw1673
The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav4881
Neurogenesis takes a hit in Alzheimer’s disease
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax1726
Exacting Edward Jenner’s revenge: The quest for a new tuberculosis vaccine
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax4219
Doubling-down on prion protein function in Alzheimer’s disease
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay3567
Somatic mutations are improving their bad rap
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax4871
Comment on “An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness”
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aav4538
From mini-brains to neural networks
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay3570
A new player in hunger games
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay3569
p21: One protein to rule cell fate
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay3568
A randomized clinical efficacy study targeting mPGES1 or EP4 in dogs with spontaneous osteoarthritis
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw9993
A gut reaction to exercise
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaz9765
Squeezing inspiration from embryonic hearts
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw5317
A primate resource for autism research
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aay3571
A killer sidekick for antitumor T cells
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aaw5325
Demystifying anhedonia in childhood with large-scale networks
来源期刊:Science Translational MedicineDOI:10.1126/scitranslmed.aax1723