Annual Review of Pharmacology and Toxicology

The Exposome: Molecules to Populations.

Pharmacologic Targeting of Hypoxia-Inducible Factors.

Organoids for Drug Discovery and Personalized Medicine.

Metals and Mechanisms of Carcinogenesis.

Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants.

Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

The Placebo Effect in Pain Therapies.

The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.

Lipid-Dependent Regulation of Ion Channels and G Protein-Coupled Receptors: Insights from Structures and Simulations.

Therapeutic Approaches to the Treatment of Tinnitus.

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.

Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning.

Systems Pharmacology: Defining the Interactions of Drug Combinations.

Beyond THC and Endocannabinoids.

Muscle Wasting Diseases: Novel Targets and Treatments.

Assessment of Pharmacokinetic Drug-Drug Interactions in Humans: In Vivo Probe Substrates for Drug Metabolism and Drug Transport Revisited.

Big Data and Artificial Intelligence Modeling for Drug Discovery.

Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.

Challenges in Orphan Drug Development: Identification of Effective Therapy for Thyroid-Associated Ophthalmopathy.

Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.

Proteasome Inhibitor Drugs.

Recent Developments in Understanding Barrier Mechanisms in the Developing Brain: Drugs and Drug Transporters in Pregnancy, Susceptibility or Protection in the Fetal Brain?

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.

Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?

Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.

(Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.

Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention.

Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.

Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Structural Basis for Allosteric Modulation of Class B G Protein-Coupled Receptors.

Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science.

β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions.

Gene-Based Dose Optimization in Children.

Artificial Intelligence in Drug Treatment.

G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level.

Barriers to Ensuring Access to Affordable Prescription Drugs.

Drug Therapies for Chronic Cholestatic Liver Diseases.

Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain.