Pharmacological targeting of the unfolded protein response for disease intervention
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0326-2
MCC950 closes the active conformation of NLRP3 to an inactive state
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0278-6
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0323-5
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0304-8
Automated structure prediction of trans-acyltransferase polyketide synthase products
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0313-7
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0263-0
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0411-6
Engineering of an oleaginous bacterium for the production of fatty acids and fuels
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0295-5
De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0388-1
A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0381-8
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0227-4
Accurate annotation of human protein-coding small open reading frames
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0425-0
A family of radical halogenases for the engineering of amino-acid-based products
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0355-x
Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-018-0206-1
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0364-9
Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0274-x
Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0386-3
A ligand gated strand displacement mechanism for ZTP riboswitch transcription control
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0382-7
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0370-y
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-018-0205-2
A programmable DNA-origami platform for studying lipid transfer between bilayers
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0325-3
Versatile biomanufacturing through stimulus-responsive cell–material feedback
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0357-8
Discovery of a first-in-class EZH2 selective degrader
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0421-4
Structural basis of a small molecule targeting RNA for a specific splicing correction
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0384-5
A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0413-4
Pass-back chain extension expands multi-modular assembly line biosynthesis
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0385-4
Side-chain determinants of biopolymer function during selection and replication
来源期刊:Nature chemical biologyDOI:10.1038/s41589-019-0229-2
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0365-8
Axonal iron transport in the brain modulates anxiety-related behaviors
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0371-x
Molecular basis for interactions between an acyl carrier protein and a ketosynthase
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0301-y
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0424-1
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0380-9
Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.
来源期刊:Nature Chemical BiologyDOI:10.2210/PDB5Z83/PDB
Dynamics of transcription–translation coordination tune bacterial indole signaling
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0430-3
Stick it to E3s
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0312-8
A newborn RNA switches its fate
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0391-6
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0329-z
Extracellular phosphorylation in axon pathfinding
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0383-6
HIV seals an envelope
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0238-1
Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0255-0
Disorder guides order
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0398-z
An inside job
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0395-2
Understanding the language of drugged plants
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0389-0
Poked to death
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0397-0
Breaking up is hard to do
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0351-1
Cannabinoids on the rise
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0280-z
Processing for destruction
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0428-x
A super-powered S-layer
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0236-3
T(oo)bAd
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0347-x
Snappy cell division in Actinobacteria
来源期刊:Nature Chemical BiologyDOI:10.1038/s41589-019-0226-5