MUTAGENESIS

ZnO nanoparticles-associated mitochondrial stress-induced apoptosis and G2/M arrest in HaCaT cells: a mechanistic approach.

Impact of hypoxia on DNA repair and genome integrity.

The missing heritability of familial colorectal cancer

Genetic variants in microRNAs are associated with cervical cancer risk.

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?*

Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases.

Altered DNA ligase activity in human disease.

Exosomal microRNAs and other non-coding RNAs as colorectal cancer biomarkers: a review.

XPD/ERCC2 mutations interfere in cellular responses to oxidative stress.

New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps.

Computing similarity between structural environments of mutagenicity alerts

The activating transcription factor 2: an influencer of cancer progression

Vitamin D3 as adjuvant in the treatment of type 2 diabetes mellitus: modulation of genomic and biochemical instability.

Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance.

Chromatin and other obstacles to base excision repair: potential roles in carcinogenesis.

An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests.

DNA damage and repair in neuropsychiatric disorders. What do we know and what are the future perspectives?

A decision tree–based integrated testing strategy for tailor-made carcinogenicity evaluation of test substances using genotoxicity test results and chemical spaces

Distinct pathways associated with chromosomal aberration frequency in a cohort exposed to genotoxic compounds compared to general population.

A practice of expert review by read-across using QSAR Toolbox

Response of Sulfolobus solfataricus Dpo4 polymerase in vitro to a DNA G-quadruplex.

In silico model for mutagenicity (Ames test), taking into account metabolism

Comparative study of toxicological assessment of yttrium oxide nano- and microparticles in Wistar rats after 28 days of repeated oral administration.

Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae.

The processes associated with lipid peroxidation in human embryonic lung fibroblasts, treated with polycyclic aromatic hydrocarbons and organic extract from particulate matter.

Validity of reported indicators of pesticide exposure and relevance for cytotoxic and genotoxic effects on buccal cells.

Urinary N7-(1-hydroxy-3-buten-2-yl) guanine adducts in humans: temporal stability and association with smoking.

Inclusion of an extended treatment with recovery improves the results for the human peripheral blood lymphocyte micronucleus assay.

Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage.

DNA polymerases in the risk and prognosis of colorectal and pancreatic cancers.

In silico approaches to genetic toxicology: progress and future.

The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.

DNA damage in human whole blood caused by radiopharmaceuticals evaluated by the comet assay

Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells.

Extracranial arteriovenous malformations: from bedside to bench.

Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells.

Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructed human skin tissue models.

Protein interactions in T7 DNA replisome inhibit the bypass of abasic site by DNA polymerase.

Genotoxicity assessment of four novel quinazoline-derived trypanocidal agents in the Drosophila wing somatic mutation and recombination test.

Genetic epidemiology of colorectal cancer and associated cancers.

KRAS pathway expression changes in pancreatic cancer models by conventional and experimental taxanes.

Extrapolation of in vitro structural alerts for mutagenicity to the in vivo endpoint

Validation of the performance of TIMES genotoxicity models with EFSA pesticide data

Leukaemic and bone marrow stromal cells alter cytarabine genotoxicity and cytotoxicity in favour of disease

The 3D reconstructed skin micronucleus assay: considerations for optimal protocol design.

Change in mutation frequency at a TP53 hotspot during culture of ENU-mutagenised human lymphoblastoid cells.

Important considerations for the validation of QSAR models for in vitro mutagenicity