METABOLIC ENGINEERING

Direct cell-to-cell exchange of matter in a synthetic Clostridium syntrophy enables CO2 fixation, superior metabolite yields, and an expanded metabolic space.

Building microbial factories for the production of aromatic amino acid pathway derivatives: From commodity chemicals to plant-sourced natural products.

Phage serine integrase-mediated genome engineering for efficient expression of chemical biosynthetic pathway in gas-fermenting Clostridium ljungdahlii.

Validating genome-wide CRISPR-Cas9 function improves screening in the oleaginous yeast Yarrowia lipolytica.

Engineering the morphology and metabolism of pH tolerant Ustilago cynodontis for efficient itaconic acid production.

Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine.

Exceptional solvent tolerance in Yarrowia lipolytica is enhanced by sterols.

Construction of a fusion enzyme for astaxanthin formation and its characterisation in microbial and plant hosts: A new tool for engineering ketocarotenoids

Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum.

Tailoring the Saccharomyces cerevisiae endoplasmic reticulum for functional assembly of terpene synthesis pathway.

Metabolic flux responses to deletion of 20 core enzymes reveal flexibility and limits of E. coli metabolism.

Chromosome engineering of the TCA cycle in Halomonas bluephagenesis for production of copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV).

Efficient production of 3-hydroxypropionate from fatty acids feedstock in Escherichia coli.

Cyanobacterial carboxysome mutant analysis reveals the influence of enzyme compartmentalization on cellular metabolism and metabolic network rigidity.

Genome-scale evaluation of core one-carbon metabolism in gammaproteobacterial methanotrophs grown on methane and methanol.

Engineering Lactococcus lactis for the production of unusual anthocyanins using tea as substrate.

Metabolic engineering of the type I methanotroph Methylomonas sp. DH-1 for production of succinate from methane.

Yeast chemogenomic screen identifies distinct metabolic pathways required to tolerate exposure to phenolic fermentation inhibitors ferulic acid, 4-hydroxybenzoic acid and coniferyl aldehyde.

De novo production of benzyl glucosinolate in Escherichia coli.

Transomics data-driven, ensemble kinetic modeling for system-level understanding and engineering of the cyanobacteria central metabolism.

Construction of artificial micro-aerobic metabolism for energy- and carbon-efficient synthesis of medium chain fatty acids in Escherichia coli.

Manipulation of polyhydroxyalkanoate granular sizes in Halomonas bluephagenesis.

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid.

Direct production of commodity chemicals from lignocellulose using Myceliophthora thermophila.

Production of 1,2,4-butanetriol from xylose by Saccharomyces cerevisiae through Fe metabolic engineering.

Multi-level engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the production of C9 chemicals from oleic acid.

A CRISPR/Cas9-based genome editing system for Rhodococcus ruber TH.

Upgrade of wood sugar d-xylose to a value-added nutraceutical by in vitro metabolic engineering.

Identification of Absidia orchidis steroid 11β-hydroxylation system and its application in engineering Saccharomyces cerevisiae for one-step biotransformation to produce hydrocortisone.

Engineering the early secretory pathway for increased protein secretion in Saccharomyces cerevisiae.

Combining retinal-based and chlorophyll-based (oxygenic) photosynthesis: Proteorhodopsin expression increases growth rate and fitness of a ∆PSI strain of Synechocystis sp. PCC6803.

Expanded synthetic small regulatory RNA expression platforms for rapid and multiplex gene expression knockdown.

Stimulus response-based fine-tuning of polyhydroxyalkanoate pathway in Halomonas.

Creating an in vivo bifunctional gene expression circuit through an aptamer-based regulatory mechanism for dynamic metabolic engineering in Bacillus subtilis.

Subcellular engineering of lipase dependent pathways directed towards lipid related organelles for highly effectively compartmentalized biosynthesis of triacylglycerol derived products in Yarrowia lipolytica.

Pan-cancer analysis of the metabolic reaction network.

Kick-starting evolution efficiency with an autonomous evolution mutation system.

Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic.

Combining isotopically non-stationary metabolic flux analysis with proteomics to unravel the regulation of the Calvin-Benson-Bassham cycle in Synechocystis sp. PCC 6803.

Purity by design: Reducing impurities in bioproduction by stimulus-controlled global translational downregulation of non-product proteins.

High level production of flavonoid rhamnosides by metagenome-derived Glycosyltransferase C in Escherichia coli utilizing dextrins of starch as a single carbon source.

Design and engineering of E. coli metabolic sensor strains with a wide sensitivity range for glycerate.

Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines.

Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant.

Functional expression of a bacterial α-ketoglutarate dehydrogenase in the cytosol of Saccharomyces cerevisiae.

Production of nonnatural straight-chain amino acid 6-aminocaproate via an artificial iterative carbon-chain-extension cycle.

Mapping Salmonella typhimurium pathways using 13C metabolic flux analysis.