Science Signaling

Tracing the origin and evolution of pseudokinases across the tree of life

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology

Host mitochondria influence gut microbiome diversity: A role for ROS

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment

Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4+ T cell activation

Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance

LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction

CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration

Perspectives on the role of Wnt biology in cancer

Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility

The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose

Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins

Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β

iRhom2 inhibits bile duct obstruction–induced liver fibrosis

Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms

Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4

Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity

The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair

Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity

Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils

The Ca2+ export pump PMCA clears near-membrane Ca2+ to facilitate store-operated Ca2+ entry and NFAT activation

CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

Nucleotide exchange–dependent and nucleotide exchange–independent functions of plant heterotrimeric GTP-binding proteins

Eye on ion channels in immune cells

Thiol-based direct threat sensing by the stress-activated protein kinase Hog1

Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation

Mitochondrial respiration not required

Driving expression of leptin

PAF and the inflammasome

CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2

Activating cGAS at the right time and place

Lipidating a ubiquitin ligase

Chromatin serotonylation limits differentiation

Bugs in the gut dictate food allergy

SOCE, mitochondria, and inflammation

Stress, age, and cancer

Lactylation drives resolution

Stepping out of the shadow: STIM2 promotes IL-3–induced cytokine release

Turning off cellular stress

New connections: Decoding macrophages in disease

PIEZO1 promotes inflammation