Toxicology Research

A review of arsenic exposure and lung cancer.

MiRNA-21 functions in ionizing radiation-induced epithelium-to-mesenchymal transition (EMT) by downregulating PTEN.

Comparison of hepatotoxicity and mechanisms induced by triclosan (TCS) and methyl-triclosan (MTCS) in human liver hepatocellular HepG2 cells.

Acute and 30-day oral toxicity studies of a novel coccidiostat - ethanamizuril.

Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats.

Hepatoprotective activity of raspberry ketone is mediated via inhibition of the NF-κB/TNF-α/caspase axis and mitochondrial apoptosis in chemically induced acute liver injury.

A simple model to solve a complex drug toxicity problem.

Anti-diabetic study of vitamin B6 on hyperglycaemia induced protein carbonylation, DNA damage and ROS production in alloxan induced diabetic rats.

Radon induced mitochondrial dysfunction in human bronchial epithelial cells and epithelial-mesenchymal transition with long-term exposure.

Therapeutic effects of ethanolic extract from the green cocoon shell of silkworm Bombyx mori on type 2 diabetic mice and its hypoglycaemic mechanism.

Toxicity of combined exposure of ZnO nanoparticles (NPs) and myricetin to Caco-2 cells: changes of NP colloidal aspects, NP internalization and the apoptosis-endoplasmic reticulum stress pathway.

The human body burden of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in residents’ human milk from Guangdong Province, China

Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide.

The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells.

In silico prediction of chemical aquatic toxicity for marine crustaceans via machine learning.

Study on systemic and reproductive toxicity of acetochlor in male mice

Inhibitions of HMGB1 and TLR4 alleviate DINP-induced asthma in mice.

The protective role of CsNPs and CurNPs against DNA damage, oxidative stress, and histopathological and immunohistochemical alterations induced by hydroxyapatite nanoparticles in male rat kidney.

A theoretical insight into the reaction mechanisms of a 2,4,6-trinitrotoluene nitroso metabolite with thiols for toxic effects.

Effects of indoor coal fine particulate matter on the expression levels of inflammatory factors in ovalbumin-induced mice.

TrxR2 overexpression alleviates inflammation-mediated neuronal death via reducing the oxidative stress and activating the Akt-Parkin pathway.

Distribution of toxicity values across different species and modes of action of pesticides from PESTIMEP and PPDB databases.

Photoactive CO-releasing complexes containing iron - genotoxicity and ability in HO-1 gene induction in HL-60 cells.

Dendrimer-conjugated podophyllotoxin suppresses DENA-induced HCC progression by modulation of inflammatory and fibrogenic factors.

Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage.

Androgenic/antiandrogenic activities of PAEs determined by a novel AR-mediated reporter gene assay based on LLC-MK2 cells.

Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions

Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats

Celastrol pretreatment as a therapeutic option against cisplatin-induced nephrotoxicity.

High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes in Caenorhabditis elegans.

Study of mitochondrial swelling, membrane fluidity and ROS production induced by nano-TiO2 and prevented by Fe incorporation.

The effects of lead on the development of somites in chick embryos (Gallus gallus domesticus) under in vitro conditions: a histological study.

Generation of TD50 values for carcinogenicity study data.

Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats.

Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats.

Pseudo-allergic reaction caused by Qingkailing injection partially via the PI3K-Rac1 signaling pathway in RBL-2H3 cells.

Rethinking and new perspectives on cardiotoxicity of traditional Chinese medicine

Tin thiocarbonohydrazone complexes: synthesis, crystal structures and biological evaluation.

Association of smoking with coronary artery disease in Nepalese populations: a case control study.

Benzisothiazolinone upregulates the MUC5AC expression via ERK1/2, p38, and NF-κB pathways in airway epithelial cells.

Novel evaluation of sevoflurane anesthetic exposure on the testicular germ cells of neonatal male mice.

Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics.

Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae.

Effects of lunar dust simulant on cardiac function and fibrosis in rats.

Bioactivity of a radical scavenger bis(pyrazolium p-toluenesulphonate) on ctDNA and certain microbes: a combined experimental and theoretical analysis.

Innovative models for in vitro detection of seizure.

Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway