Small GTPases

New insights into mechanisms of nuclear translocation of G-protein coupled receptors

Anchoring high concentrations of SynGAP at postsynaptic densities via liquid-liquid phase separation

Modular regulation of Rho family GTPases in development

Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network

ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells

Cross-talk between Rho GTPases and PI3K in the neutrophil

Approaches to inhibiting oncogenic K-Ras.

Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic

Arf GAPs and molecular motors

Exploring the iceberg: Prospects of coordinated myosin V and actin assembly functions in transport processes

Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells

Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level

CAP-Gly proteins contribute to microtubule-dependent trafficking via interactions with the C-terminal aromatic residue of α-tubulin

Spatial regulation of ARAF controls the MST2-Hippo pathway

Where no Ras has gone before: VPS35 steers N-Ras through the cytosol

Regulation of Rho GTPase activity at the leading edge of migrating cells by p190RhoGAP

Identification of guanine nucleotide exchange factors that increase Cdc42 activity in primary human endothelial cells.

SWAP70 is a universal GEF-like adaptor for tethering actin to phagosomes

Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells

Allosteric autoactivation of SOS and its kinetic mechanism

Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells

Recognition and stabilization of geranylgeranylated human Rab5 by the GDP Dissociation Inhibitor (GDI)

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2

Rabs on the fly: Functions of Rab GTPases during development

Paradoxical regulation of glucose-induced Rac1 activation and insulin secretion by RhoGDIβ in pancreatic β-cells.

Regulation of small GTPase activity by G1 cyclins

Mechanism of cell-intrinsic adaptation to Adams-Oliver Syndrome gene DOCK6 disruption highlights ubiquitin-like modifier ISG15 as a regulator of RHO GTPases

The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108

The ins and outs of the Arf4-based ciliary membrane-targeting complex

PKCε regulates Rho GTPases and actin cytoskeleton reorganization in non-small cell lung cancer cells.

Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis

Ras-ling with new therapeutic targets for metastasis

Rab17 mediates intermixing of phagocytosed apoptotic cells with recycling endosomes

Fgd5 is a Rac1-specific Rho GEF that is selectively inhibited by aurintricarboxylic acid.

Differential role for PAK1 and PAK4 during the invadopodia lifecycle

The small GTPase RAB-35 facilitates the initiation of phagosome maturation and acts as a robustness factor for apoptotic cell clearance.

ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses.

The UIG-1/CDC-42 guanine nucleotide exchange factor acts in parallel to CED-10/Rac1 during axon outgrowth in Caenorhabditis elegans

Aberrant Rac pathway signalling in glioblastoma.

Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells.

UnPAKing RUNX3 functions–Both sides of the coin

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding.

Non-muscle myosin II activation: adding a classical touch to ROCK.

Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling