CHEMICAL RESEARCH IN TOXICOLOGY

Wood and Biomass Smoke: Addressing Human Health Risks and Exposures.

Cause-and-effect analysis as a tool to improve the reproducibility of nanobioassays: four case studies.

Epigenetic DNA Modification N6-Methyladenine Inhibits DNA Replication by DNA Polymerase of Pseudomonas aeruginosa Phage PaP1.

Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation.

Hydrolyzable Tannins Are Iron Chelators That Inhibit DNA Repair Enzyme ALKBH2.

Sucralose-Enhanced Degradation of Electronic Cigarette Liquids during Vaping.

Identification of [6-Hydroxy-2-(hydroxymethyl)-5-oxo-5,6-dihydro-2 H-pyran-3-yl]-cysteine (HHPC) as a Cysteine-specific Modification Formed from 3,4-Dideoxyglucosone-3-ene (3,4-DGE).

Interaction of Quinone-Related Electron Acceptors with Hydropersulfide Na2S2: Evidence for One-Electron Reduction Reaction.

Exposure to Inorganic Arsenic and Lead and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis.

Tandem lesions arising from 5-(uracilyl)methyl peroxyl radical addition to guanine: Product analysis and mechanistic studies.

Comparison of CO, PAH, Nicotine, and Aldehyde Emissions in Waterpipe Tobacco Smoke Generated Using Electrical and Charcoal Heating Methods.

Free-Base Nicotine Is Nearly Absent in Aerosol from IQOS Heat-Not-Burn Devices, As Determined by 1H NMR Spectroscopy.

Involvement of pazopanib and sunitinib aldehyde reactive metabolites in toxicity and drug-drug interactions in vitro and in patient samples.

A Nitrogen Mustard Induces Formation of DNA-Histone Cross-Links in Nucleosome Core Particles.

Cell Lines as Biological Models: Practical Steps for More Reliable Research.

In vitro metabolism of auriculasin and its inhibitory effects on human cytochrome P450 and UDP-glucuronosyltransferase enzymes.

How to improve the dosing of chemicals in high-throughput in vitro mammalian cell assays.

Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.

Biological potential of novel methoxy and hydroxy substituted heteroaromatic amides designed as promising antioxidative agents: Synthesis, 3D-QSAR analysis and biological activity.

Metabolomics investigation of voriconazole-induced hepatotoxicity in mice.

Structural and Metal Ion Effects on Human Topoisomerase IIα Inhibition by α-(N)-Heterocyclic Thiosemicarbazones.

Squalene Oxidation Induced by Urban Pollutants: Impact on Skin Surface Physico-Chemistry.

Analysis of the effects of Cr(VI) exposure on mRNA modifications.

Quartz disrupts iron homeostasis in alveolar macrophages to impact a pro-inflammatory effect.

The Chrysin effect in prevention of acetaminophen-induced hepatotoxicity in rat.

Quantitation of N6-Formyl-Lysine Adduct Following Aristolochic Acid Exposure in Cells and Rat Tissues by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope-Dilution Method.

Metabolite Profiling and Reaction Phenotyping for the in vitro Assessment of the Bioactivation of Bromfenac.

Carbon disulfide induces embryo implantation disorder by disturbing the polarization of macrophages in mice uterus.

Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.

Toxicokinetic–Toxicodynamic Modeling of the Effects of Pesticides on Growth of Rattus norvegicus

UPLC-Q-TOF/MS based metabolomics approach to study the hepatotoxicity of cantharidin on mice.

Quantitation of Lipid Peroxidation Product DNA Adducts in Human Prostate by Tandem Mass Spectrometry: A Method that Mitigates Artifacts.

Tofacitinib is a Mechanism-Based Inactivator of Cytochrome P450 3A4 - Revisiting the Significance of the Epoxide Intermediate and Glutathione Trapping.

Effects of 26 recombinant CYP3A4 variants on brexpiprazole metabolism.

Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1.

CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish.

Structural Foundation for Insect-Selective Activity of Acylpolyamine Toxins from Spider Araneus ventricosus.

Proteasome 20S and Rab5 alteration after 24 h and 14 days chlorpyrifos exposure lead to β-amyloid and Tau protein levels increase and SN56 neuronal cell death.

GMDTC attenuates cisplatin-induced systemic toxicity without affecting antitumor efficacy.

Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?

A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes.

Targeted Quantitative Proteomics Revealed Arsenite-induced Proteasomal Degradation of RhoB in Fibroblast Cells.

In vitro Biotransformation of the Nrf2 activator Bardoxolone: Formation of an Epoxide Metabolite that Undergoes Two Novel Glutathione-Mediated Metabolic Pathways; Epoxide Reduction and Oxidative Elimination of Nitrile Moiety.

In situ Fluorescence Tracking Toxic Metabolite mono-2-ethylhexyl phthalate (MEHP) of di (2-ethylhexyl) phthalate (DEHP) in HeLa Cells.

Development of a Novel Shallow Liquid Interface Exposure System for MWCNT Toxicity Assessment.

Mass spectrometry characterization of thiol conjugates linked to poly-oxygenated PUFA species.

Concentration-Dependent Dual Effects of Ciprofloxacin on SB-590885-Resistant BRAFV600E A375 Melanoma Cells.