AGING CELL

Astrocyte senescence: Evidence and significance

Sirt1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

Born this way: Hippocampal neurogenesis across the lifespan

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Acarbose improves health and lifespan in aging HET3 mice

An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program

Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease

Drosophila insulin‐like peptide dilp1 increases lifespan and glucagon‐like Akh expression epistatic to dilp2

IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Are skin senescence and immunosenescence linked within individuals?

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells

The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation

Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila

Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice

HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy

Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity

Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR‐125b pathway

Functional microbiome deficits associated with ageing: Chronological age threshold

Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

LncRNAs regulating stemness in aging

Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection

Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF‐1 pathway

Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a

Senescent cells: A new Achilles’ heel to exploit for cancer medicine?

Cell‐type‐specific role of lamin‐B1 in thymus development and its inflammation‐driven reduction in thymus aging

Improved mitochondrial stress response in long‐lived Snell dwarf mice

Global metabolic profiling to model biological processes of aging in twins

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation

α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1

MPK‐1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction

Longevity‐related molecular pathways are subject to midlife “switch” in humans

Carbon monoxide attenuates amyloidogenesis via down‐regulation of NF‐κB‐mediated BACE1 gene expression

Rag1 immunodeficiency‐induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress

Changes in presynaptic calcium signalling accompany age‐related deficits in hippocampal LTP and cognitive impairment

Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells

Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation

Aging differentially modulates the Wnt pro‐survival signalling pathways in vascular smooth muscle cells

PGC‐1a integrates a metabolism and growth network linked to caloric restriction

Compromised steady‐state germinal center activity with age in nonhuman primates

RanGAP‐mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain

Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts

A genome‐wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells