Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09626-7
Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09627-6
Challenge model of TNFα turnover at varying LPS and drug provocations
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09622-x
Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09634-7
Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09629-4
Operating characteristics of stepwise covariate selection in pharmacometric modeling
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09635-6
A translational platform PBPK model for antibody disposition in the brain
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09641-8
Orphan drug development: the increasing role of clinical pharmacology
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09646-3
Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09642-7
Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09630-x
Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09637-4
Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09636-5
Cabozantinib exposure–response analyses of efficacy and safety in patients with advanced hepatocellular carcinoma
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09659-y
Development of visual predictive checks accounting for multimodal parameter distributions in mixture models
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09632-9
Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09650-7
Mathematical modeling of the glucagon challenge test
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09655-2
Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09633-8
Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09652-5
Bioequivalence for highly variable drugs: regulatory agreements, disagreements, and harmonization
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09623-w
Reproducible pharmacokinetics
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09621-y
A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09649-0
Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09666-z
Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09647-2
Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09640-9
Journal editor’s final report
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09665-0
Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09644-5
Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09653-4
Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09638-3
FDA’s Office of Orphan Products Development: providing incentives to promote the development of products for rare diseases
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09645-4
Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09657-0
Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09619-6
Bayesian approach to investigate a two-state mixed model of COPD exacerbations
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09643-6
Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09656-1
Panos Macheras: a pioneering scientist in pharmaceutical science
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09628-5
Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09663-2
Structural identifiability and sensitivity
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09624-9
Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09648-1
A quantitative systems pharmacology model of colonic motility with applications in drug development
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09651-6
Preface to Special Issue for Panos Macheras
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09631-w
Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09662-3
Impact of Phase 1 study design on estimation of QT interval prolongation risk using exposure–response analysis
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09661-4
Correction to: Bayesian approach to investigate a two-state mixed model of COPD exacerbations
来源期刊:Journal of Pharmacokinetics and PharmacodynamicsDOI:10.1007/s10928-019-09664-1