Molecular and Cellular Oncology

The role of R-loops in transcription-associated DNA double-strand break repair

Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c

Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer

Mechanical forces rewire metabolism in the tumor niche

Does cancer cell-expressed SLAMF7 impact on CD47-mediated phagocytosis?

Connect-four: genomic analyses of regenerating stem cells identifies zygotic Dux factors as tumor initiators

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Dual role of N-acetyl-aspartyl-glutamate metabolism in cancer monitor and therapy

Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy

Yeast cells can partially revert chromosome segregation to repair late DNA double-strand breaks through homologous recombination

Phosphatidic acid: a lipid regulator of the Hippo pathway

The elusive “hunger protein”: an appetite-stimulatory factor that is overabundant in human obesity

Hepatocytes prepare the soil for liver metastasis

mTORC1-driven accumulation of the oncometabolite fumarate as a potential critical step in renal cancer progression

Patient-derived xenografts: a promising resource for preclinical cancer research

FBXW2 suppresses proliferation and invasion of lung cancer cells by targeting SKP2 and β-catenin

Transcriptomic profile of intrinsically chemoresistant acute myeloid leukemia patients

Cancer stem cells: here, there, and everywhere

MLN4924: additional activities beyond neddylation inhibition

Glutamine addiction: an Achilles heel in esophageal cancers with dysregulation of CDK4/6

Genome instability triggered by the V(D)J recombination by-product

Senescence controls prostatic neoplasia driven by Pten loss

Tafazzin modulates cellular phospholipid composition to regulate AML stemness

When fat goes down, prostate cancer is on the ropes

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation

Structure and function of a monocarboxylate transporter homolog specific for L-lactate

Systems Biology approaches to cancer: towards new therapeutical strategies and personalized approaches

Beyond growth signaling: apoptotic sensor MERTK activates AKT by a novel mechanism

Autophagy represses hepatic carcinogenesis

Tumor suppression by control of matrix metalloproteinase recycling

Nucleoli and Promyelocytic Leukemia Protein (PML) bodies are phase separated nuclear protein quality control compartments for misfolded proteins

Tumor growth fueled by spurious senescence phenotypes

Targeting HER2 beyond breast cancer

A liquid biopsy assay for identifying early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals

Compartmentalized DNA repair: Rif1 S-acylation links DNA double-strand break repair to the nuclear membrane

One way to rule them all: G2/M gene regulation by oncogenic YAP1 and B-MYB

Wave of the future: involvement of actin polymerization in the regulation of tissue growth and shape

Finding MYCure

CD13 regulation of membrane recycling: implications for cancer dissemination

Dephosphorylation of the Atg1 kinase complex by type 2C protein phosphatases

LncRNAs join hands together to regulate neuroblastoma progression

HectH9 hijacks glucose metabolism to fuel tumor growth

Another string to the polo bow: a new mitotic role of PLK1 in centromere protection

Author’s view: epithelial plasticity metabolically reprograms normal cells towards a neoplastic-prone state