GENES & DEVELOPMENT

Host-transposon interactions: conflict, cooperation, and cooption.

Transcription-mediated replication hindrance: a major driver of genome instability.

CD44 splice isoform switching determines breast cancer stem cell state.

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52.

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening.

Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer-enhancer interactions.

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer.

Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells.

Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis.

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.

A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repair.

Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors.

Kidney organoids: accurate models or fortunate accidents.

Molecular regulation of peripheral B cells and their progeny in immunity.

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis.

Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes.

Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.

RNAi-dependent Polycomb repression controls transposable elements in Tetrahymena.

Metabolic dependencies and vulnerabilities in leukemia.

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis.

Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID.

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export.

Afadin cooperates with Claudin-2 to promote breast cancer metastasis.

BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity.

Control of homologous recombination by the HROB-MCM8-MCM9 pathway.

An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion.

The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation.

The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.

Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination.

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth.

Resolution of human ribosomal DNA occurs in anaphase, dependent on tankyrase 1, condensin II, and topoisomerase IIα.

Human NORs, comprising rDNA arrays and functionally conserved distal elements, are located within dynamic chromosomal regions.

A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.

GADD45 promotes locus-specific DNA demethylation and 2C cycling in embryonic stem cells.

Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6.

Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding.

Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling.

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.

TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth/differentiation and breast cancer development.

PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability.

Phasing in heterochromatin during development.

A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.

Ways to unwind with HROB, a new player in homologous recombination.