Future Medicinal Chemistry

Gaseous signaling molecules and their application in resistant cancer treatment: from invisible to visible.

Recent advances of thiazole hybrids in biological applications.

Synthesis, in vitro and in silico studies of HO-1 inducers and lung antifibrotic agents.

State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures.

Insights for the design of protein lysine methyltransferase G9a inhibitors.

ADMET profiling of geographically diverse phytochemical using chemoinformatic tools.

Targeting pteridine reductase 1 and dihydrofolate reductase: the old is a new trend for leishmaniasis drug discovery.

Phosphonate prodrugs: an overview and recent advances.

Lights and shadows of electrophile signaling: focus on the Nrf2-Keap1 pathway.

Energy windows for computed compound conformers: covering artefacts or truly large reorganization energies?

How to replace the lost keys? Strategies toward safer KV7 channel openers.

Glycans in nanomedicine, impact and perspectives.

Foamy matters: an update on Quillaja saponins and their use as immunoadjuvants.

Indole-3-glyoxyl tyrosine: synthesis and antimalarial activity against Plasmodium falciparum.

Sugar ligand-mediated drug delivery.

Can multiscale simulations unravel the function of metallo-enzymes to improve knowledge-based drug discovery?

Synthesis, anticancer activity, structure-activity relationship and binding mode of interaction studies of substituted pentanoic acids.

Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents.

Fluorinated MRI contrast agents and their versatile applications in the biomedical field.

Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green.

Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes.

Visnagin and benzofuran scaffold-based molecules as selective cyclooxygenase-2 inhibitors with anti-inflammatory and analgesic properties: design, synthesis and molecular docking.

Targeting uracil-DNA glycosylases for therapeutic outcomes using insights from virus evolution.

Development and strategies of CDK4/6 inhibitors.

Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials

Site-specific chemoproteomic profiling of targets of glyoxal.

Inhibiting two cellular mutant epidermal growth factor receptor tyrosine kinases by addressing computationally assessed crystal ligand pockets.

Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors.

Synthesis and DNase I inhibitory properties of new benzocyclobutane-2,5-diones.

Rhodamine probes for Fe3+: theoretical calculation for specific recognition and instant fluorescent bioimaging.

The nonepigenetic role for small molecule histone deacetylase inhibitors in the regulation of cardiac function.

Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria.

The progresses in curcuminoids-based metal complexes: especially in cancer therapy.

Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction.

Discovery of class I histone deacetylase inhibitors based on romidpesin with promising selectivity for cancer cells.

Synthesis and vasodilator activity of some pyridazin-3(2H)-one based compounds.

Computational insight into the anticholinesterase activities and electronic properties of physostigmine analogs.

Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines.

New pyrimidines and triazolopyrimidines as antiproliferative and antioxidants with cyclooxygenase-1/2 inhibitory potential.

From biomedicinal to in silico models and back to therapeutics: a review on the advancement of peptidic modeling.

Ensemble docking-based virtual screening toward identifying inhibitors against Wee1 kinase.

Design, synthesis and evaluation of belinostat analogs as histone deacetylase inhibitors.

Continuous molecular fields and the concept of molecular co-fields in structure-activity studies.

The synthesis and biological evaluation of a new bioactive metabolite of mosapride as a potential gastroprokinetic agent.

How could histone deacetylase activators be useful leads in the search for new therapeutics?

Synthesis and structure-activity relationships of novel abietane diterpenoids with activity against Staphylococcus aureus.

Modulation of the coronary tone in the expanding scenario of Chromogranin-A and its derived peptides.