Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12692
Design and Conduct Considerations for First‐in‐Human Trials
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12582
Continuous Monitoring Using a Wearable Device Detects Activity‐Induced Heart Rate Changes After Administration of Amphetamine
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12673
The Biomedical Data Translator Program: Conception, Culture, and Community
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12592
A Modeling Framework to Characterize Cytokine Release upon T‐Cell–Engaging Bispecific Antibody Treatment: Methodology and Opportunities
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12662
Use of Titration as a Therapeutic Individualization Strategy: An Analysis of Food and Drug Administration–Approved Drugs
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12626
Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12594
VKORC1 and Novel CYP2C9 Variation Predict Warfarin Response in Alaska Native and American Indian People
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12611
PF‐04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo‐Controlled Study
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12604
Clinical Utility of Pharmacogene Panel‐Based Testing in Patients Undergoing Percutaneous Coronary Intervention
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12729
The Labyrinth of Product Development and Regulatory Approvals in Liquid Biopsy Diagnostics
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12657
Identification and Evaluation of Clinical Substrates of Organic Anion Transporting Polypeptides 1B1 and 1B3
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12623
Psychological and Genetic Predictors of Pain Tolerance
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12605
Interaction Between Sex and Organic Anion‐Transporting Polypeptide 1b2 on the Pharmacokinetics of Regorafenib and Its Metabolites Regorafenib‐N‐Oxide and Regorafenib‐Glucuronide in Mice
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12630
Prediction of Nephropathy in Type 2 Diabetes: An Analysis of the ACCORD Trial Applying Machine Learning Techniques
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12647
Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12616
Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12645
Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12722
Regulatory Affairs 101: Introduction to Investigational New Drug Applications and Clinical Trial Applications
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12635
No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug–Drug Interaction Study
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12646
Characteristics of Single Pivotal Trials Supporting Regulatory Approvals of Novel Non‐orphan, Non‐oncology Drugs in the European Union and United States from 2012−2016
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12617
Translating Minimally Invasive Glaucoma Surgery Devices
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12660
CYP2B6 Genotype‐Dependent Inhibition of CYP1A2 and Induction of CYP2A6 by the Antiretroviral Drug Efavirenz in Healthy Volunteers
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12671
Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12691
The FDA’s Regulatory Framework for Chimeric Antigen Receptor‐T Cell Therapies
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12666
Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12590
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12649
Reduced Risk of Sinusoidal Obstruction Syndrome of the Liver after Busulfan‐Cyclophosphamide Conditioning Prior to Allogeneic Hematopoietic Stem Cell Transplantation
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12709
Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12665
Unveiling the Genetic Architecture of Human Disease for Precision Medicine
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12593
Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12716
Impact of Disease and Treatment Response in Drug–Drug Interaction Studies: Osimertinib and Simvastatin in Advanced Non‐Small Cell Lung Cancer
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12688
Models of Variability and Circadian Rhythm in Heart Rate, Blood Pressure, and QT Interval for Healthy Subjects Who Received Placebo in Phase I Trials
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12640
siRNA Targeting and Treatment of Gastrointestinal Diseases
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12668
Dosage Regimens for Meropenem in Children with Pseudomonas Infections Do Not Meet Serum Concentration Targets
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12710
Effect of Acid‐Suppressive Strategies on Pazopanib Efficacy in Patients With Soft‐Tissue Sarcoma
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12648
Analysis of Global Drug Development Pathways and Postmarketing Safety in Japan: Local Studies May Reduce Drug‐Related Deaths
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12631
Effect of Genetic and Nongenetic Factors on the Clinical Response to Mineralocorticoid Receptor Antagonist Therapy in Egyptians with Heart Failure
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12702
A Physiologically‐Based Pharmacokinetic Model for Targeting Calcitriol‐Conjugated Quantum Dots to Inflammatory Breast Cancer Cells
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12664
Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate‐Lowering Response—In Search of a Minimum Effective Oxypurinol Concentration
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12686
I‐Corps at NIH: Entrepreneurial Training Program Creating Successful Small Businesses
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12637
Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12727
From Patient to Molecule: In Pursuit of Universal Treatments for TB
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12718
Involve Children and Parents in Clinical Studies
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12696
Pivotal Considerations for Optimal Deployment of Healthy Volunteers in Oncology Drug Development
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12703
A Proposal of Conducting Bioequivalence Trials with Gastric pH Modulators for Two Oral Formulations Demonstrating Different Dissolution Profiles at Elevated pH
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12658
Comparing Model Performance in Characterizing the PK/PD of the Anti‐Myostatin Antibody Domagrozumab
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12693
The Advantages and Challenges of Using Real‐World Data for Patient Care
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12683
Odds of Acute Kidney Injury in Patients Receiving Dipeptidyl Peptidase 4 Inhibitors: A National Cohort Study Within the Department of Veterans Affairs
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12676
Prediction of Metabolite‐to‐Parent Drug Exposure: Derivation and Application of a Mechanistic Static Model
来源期刊:Clinical and Translational ScienceDOI:10.1111/cts.12734