Signal Transduction and Targeted Therapy

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

PROTACs: great opportunities for academia and industry

Targeted therapeutic options and future perspectives for HER2-positive breast cancer

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

The roles of exosomal miRNAs and lncRNAs in lung diseases

Targeting growth hormone function: strategies and therapeutic applications

Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9.

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer.

Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.

The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts

Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapy

Off-Targeting of Base Editors: BE3 but not ABE induces substantial off-target single nucleotide variants

Serotonylation: A novel histone H3 marker

Saikosaponin D suppresses enterovirus A71 infection by inhibiting autophagy

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death

Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer

Clonal replacement of novel T cells: a new phenomenon in the tumor microenvironment following PD-1 blockade

The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia

The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis

Author Correction: History and progress of hypotheses and clinical trials for Alzheimer’s disease

miR-124/VAMP3 is a novel therapeutic target for mitigation of surgical trauma-induced microglial activation

Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer

Genetically engineered T cells for cancer immunotherapy

Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 in Pneumocystis carinii

Allelic frequency differences of DAOA variants between Caucasians and Asians and their association with major mood disorders

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness

Peptides encoded by noncoding genes: challenges and perspectives

Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells.

The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports.

Pazopanib in advanced soft tissue sarcomas.

Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma.

Coagulation factors: a novel class of endogenous host antimicrobial proteins against drug-resistant gram-negative bacteria

Author Correction: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity.

Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway

DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy.