Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.10.003
Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.
来源期刊:Cell chemical biologyDOI:10.1016/J.CHEMBIOL.2019.05.005
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.02.009
Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.02.012
MemBright: A Family of Fluorescent Membrane Probes for Advanced Cellular Imaging and Neuroscience.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.01.009
Labeling Strategies Matter for Super-Resolution Microscopy: A Comparison between HaloTags and SNAP-tags
来源期刊:Cell Chemical BiologyDOI:10.1016/j.chembiol.2019.01.003
Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.015
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.02.018
Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.012
Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.02.001
Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.11.005
Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.
来源期刊:Cell chemical biologyDOI:10.1016/J.CHEMBIOL.2019.03.011
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.12.001
Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.004
Allosteric Inhibition of Ubiquitin-like Modifications by a Class of Inhibitor of SUMO-Activating Enzyme.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.10.026
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo
来源期刊:Cell Chemical BiologyDOI:10.1016/j.chembiol.2018.12.002
Unique Binding Specificities of Proteins toward Isomeric Asparagine-Linked Glycans.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.01.002
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.11.014
A Bump-Hole Approach for Directed RNA Editing.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.10.025
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.10.002
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.014
A Chemical Strategy for Protease Substrate Profiling.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.03.007
What Makes a Kinase Promiscuous for Inhibitors?
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.005
Detection of Low-Abundance Metabolites in Live Cells Using an RNA Integrator.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.01.005
Antitubercular Triazines: Optimization and Intrabacterial Metabolism.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.10.010
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.07.013
Role of Bile in Infectious Disease: the Gall of 7α-Dehydroxylating Gut Bacteria.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.12.010
Complex Formation between VEGFR2 and the β2-Adrenoceptor
来源期刊:Cell Chemical BiologyDOI:10.1016/j.chembiol.2019.02.014
G-quadruplexes Sequester Free Heme in Living Cells.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.10.003
Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.09.008
Toxic Activation of an AAA+ Protease by the Antibacterial Drug Cyclomarin A.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.05.008
Customizing Functionalized Cofactor Mimics to Study the Human Pyridoxal 5′-Phosphate-Binding Proteome
来源期刊:Cell Chemical BiologyDOI:10.1016/j.chembiol.2019.08.003
Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.01.012
Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.12.003
Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.11.003
Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.11.012
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.04.003
Membrane-Active Rhamnolipids Overcome Aminoglycoside Resistance.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.09.015
A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.11.008
Death by Retrograde Transport: Avoiding the Apoptosis Default.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.12.002
Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.02.006
Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.10.004
Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.10.012
Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.12.001
Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.09.011
How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.09.001
Mechanistic MALDI-TOF Cell-Based Assay for the Discovery of Potent and Specific Fatty Acid Synthase Inhibitors.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.06.004
Probing Substrate Preferences of Depalmitoylases.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2018.12.008
Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.07.003
Improved ThwaRTing of Genome Symbionts.
来源期刊:Cell chemical biologyDOI:10.1016/j.chembiol.2019.07.014