JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Nanoparticle contrast-enhanced micro-CT: A preclinical tool for the 3D imaging of liver and spleen in longitudinal mouse studies.

Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform.

Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms.

Individual variability in female and male mice in a test-retest protocol of the forced swim test.

Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured.

Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human.

The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: Pharmacological validation data and a comparison of methods.

Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.

Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish.

Impact of disease state on arrhythmic event detection by action potential modelling in cardiac safety pharmacology.

A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention.

High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons.

In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay.

Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugs.

Novel methods for the assessment of safety pharmacology and toxicology parameters in anesthetized and ventilated dogs receiving inhaled drugs.

FOB vs modified Irwin: What are we doing?

Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay.

Assessment of non-negative matrix factorization for the preprocessing of long-term ECG.

Relative equivalence of CNS safety (FOB) assessment outcomes in male and female Wistar-Han and Sprague-Dawley rats.

Availability of multistep light stimulus method for evaluation of visual dysfunctions.

Potency of Late-Nav1.5 current inhibition depends on the agonist used to augment it.

A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6.

Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds.

Generation of a robust model for inducing autoimmune arthritis in Sprague Dawley rats.

Development of zebrafish demyelination model for evaluation of remyelination compounds and RORγt inhibitors.

Establishing performance characteristics for positive control article selection in drug self-administration studies.

Discrimination of the effects of three cardiac ion channel blockers using ECG biomarkers and arrhythmia incidence in St. Kitts green monkeys (Chlorocebus Sabaeus).

Response of safety pharmacologists to challenges arising from the rapidly evolving changes in the pharmaceutical industry.

Exploratory EEG studies for the assessment of neurological liabilities in conscious dogs in early drug development.

A novel experimental intraperitoneal infection model for Haemophilus parasuis in neutropenic guinea pigs.

Comparison of several immunoassays used in drugs of abuse screening: Assessment against gold standard methods and calculation of measurement uncertainty.

The method of long-term catheterization of the vena jugularis in pigs.

Effects of common confounders on JTp and Tpe as novel proarrhythmia biomarkers.

Proof of concept comprehensive ex vivo neurological assay.

Mixed-effects modeling for concentration effect profiling in cardiomyocyte contractility assays.

Action potential response of human induced-pluripotent stem cell derived cardiomyocytes to the 28 CiPA compounds: A non-core site data report of the CiPA study.

Radiolabelling and immunohistochemistry reveal platelet recruitment into lungs and platelet migration into airspaces following LPS inhalation in mice.

Utilization of a mouse/human chimeric model for long term metabolic testing of human skin.

Robust estimation of field potential duration in multi-electrode array signals.

Surface lead EEGs: Will it stick?

Label-free dynamic mass redistribution analysis of endogenous adrenergic receptor signaling in primary preadipocytes and differentiated adipocytes.

Investigating the applicability of different amounts of solutions used in experiments, which performed in rat knee joints: Determining the optimal intraarticular injection volume.

Relationship of clinical adverse event reports to models of arrhythmia risk.

Oral vs. intraperitoneal dosing in the rat drug discrimination model.

Consensus, debates and controversies with nonclinical proarrhythmia assays.

Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies.