The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00140
Batch and Continuous Flow Production of 5-Hydroxymethylfurfural from a High Concentration of Fructose Using an Acidic Ion Exchange Catalyst
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00044
Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00132
Reactive Crystallization of Paracetamol in a Continuous Oscillatory Baffled Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00446
Basic Anion-Exchange Resin-Catalyzed Aldol Condensation of Aromatic Ketones with Aldehydes in Continuous Flow
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00048
H–D Exchange Deuteration of Arenes at Room Temperature
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00383
Improved Understanding of Cefixime Trihydrate Reactive Crystallization and Process Scale-up with the Aid of PAT
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00190
A Novel Water-Dispersible/Magnetically Recyclable Pd Catalyst for C–C Cross-Coupling Reactions in Pure Water
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00426
A Comparative Evaluation of Hydrogenation of 3-Butyn-2-ol over Pd/Al2O3 in an Oscillatory Baffled Reactor and a Commercial Parr Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00324
Development of an Effective Scalable Enantioselective Synthesis of the HIV-1 Entry Inhibitor BNM-III-170 as the Bis-Trifluoroacetate Salt.
来源期刊:Organic process research & developmentDOI:10.1021/acs.oprd.9b00353
Oxidative Cleavage of Long-Chain Terminal Alkenes to Carboxylic Acids
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00368
Concise Synthesis of a Potential 5-Lipoxygenase Activating Protein (FLAP) Inhibitor and Its Analogs through Late-Stage Alkene Dicarbofunctionalization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00199
Development of Continuous Filtration in a Novel Continuous Filtration Carousel Integrated with Continuous Crystallization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00342
Scalable Wolff–Kishner Reductions in Extreme Process Windows Using a Silicon Carbide Flow Reactor
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00336
FROM MEASUREMENTS TO STANDARDISED MULTI-DOMAIN COMPACT MODELS OF LEDS USING LED E-DATASHEETS
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP52
Application of Thiol-Modified Dual-Pore Silica Beads as a Practical Scavenger of Leached Palladium Catalyst in C–C Coupling Reactions
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00291
APPROACH TO ANALYSE SEASONAL AND GEOGRAPHICAL VARIATIONS IN DAYLIGHT ILLUMINANTS
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP31
Development of a Scalable Synthesis for the Potent Kinase Inhibitor BMS-986236; 1-(5-(4-(3-Hydroxy-3-methylbutyl)-1H-1,2,3-triazol-1-yl)-4-(isopropylamino)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00023
Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00424
Systematic Optimization of a Robust Telescoped Process for a BTK Inhibitor with Atropisomer Control by High-Throughput Experimentation, Design of Experiments, and Linear Regression
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00398
Diffusion-Enhanced Amide Bond Formation on a Solid Support
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00398
Assessment of Breast Cancer Treatment Outcome at Tikur Anbessa Specialized Hospital Adult Oncology Unit, Addis Ababa, Ethiopia
来源期刊:Organic Process Research & DevelopmentDOI:10.1097/OP9.0000000000000013
Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00193
A Practical and Robust Multistep Continuous Processfor Manufacturing 5‑Bromo‑ N ‑( tert -butyl)pyridine-3-sulfonamide
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00254
Development and Implementation of a Quality Control Strategy for an Atropisomer Impurity Grounded in a Risk-Based Probabilistic Design Space
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00293
Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00188
Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1H-pyrazol-1-yl)pyridine
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00127
Energy saving potential for integrated daylighting and electric lighting design via user-driven solutions: A literature review.
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP32
Polymorph Control in MSMPR Crystallizers. A Case Study with Paracetamol
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00351
A Holistic Approach to Streamlining Pharmaceutical Processes: A Conversation
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00440
Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00444
Anion Metathesis of Diaryliodonium Tosylate Salts with a Solid-Phase Column Constructed from Readily Available Laboratory Consumables
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00163
Multikilogram-Scale Preparation of AZD4635 via C–H Borylation and Bromination: The Corrosion of Tantalum by a Bromine/Methanol Mixture
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00342
SEMANTIC INTERPRETATION OF THE CIE 2017 COLOUR FIDELITY INDEX
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP37
Structural Correction and Process Improvement for Control of a Critical Process Impurity of Ezetimibe
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00024
Numerical and Experimental Quantification of the Performance of Microreactors for Scaling-up Fast Chemical Reactions
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00356
Further Optimization of a Scalable Biocatalytic Route to (3R)-N-Boc-3-aminoazepane with Immobilized ω-Transaminase
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00411
The Destiny of Palladium: Development of Efficient Palladium Analysis Techniques in Enhancing Palladium Recovery
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00204
Improved Manufacturing Route and Polymorphic Control of a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor ASP3026
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00427
Synergistic Solvation Effects: Enhanced Compound Solubility Using Binary Solvent Mixtures
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00077
LUMINOUS INTENSITY COMPARISON BASED ON NEW STANDARD LAMPS WITH LED REFERENCE SPECTRUM
来源期刊:Organic Process Research & DevelopmentDOI:10.25039/X46.2019.OP13
BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.9B00201
Mutagenic Impurities in 1-Hydroxybenzotriazole (HOBt)
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00376
T3P-Mediated N–N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5-a]pyridines
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.9b00396
Efficient Azacycle Formations Developed in Japanese Pharmaceutical Industries: Elegancy, Logistics, and Training (ELT) “Sandwich” for Process Chemists
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00412
Performance Characterization of Static Mixers in Precipitating Environments
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00267
De trabajadores a proveedores. La responsabilidad social empresarial y la tercerización laboral en los ingenios azucareros
来源期刊:Organic Process Research & DevelopmentDOI:10.12804/OP9789587843217
Development of a Synthetic Process for K-8986, an H1-Receptor Antagonist
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00380
Efficient and Scalable Synthesis of Glucokinase Activator with a Chiral Thiophenyl-Pyrrolidine Scaffold
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/acs.oprd.8b00354
Effects of Scale, Equipment, and Operation on Agglomeration during a Reactive Crystallization
来源期刊:Organic Process Research & DevelopmentDOI:10.1021/ACS.OPRD.8B00227